Hydrazine hydrate (1:1) → HCID 20352614, compound

HRID 1283394Notes

Reaction equation

HRID 1283394 reaction equation
[CH:1]1([C:6]2[CH:18]=[CH:17][C:9]([C:10]([CH2:12][CH2:13][C:14](O)=[O:15])=O)=[CH:8][CH:7]=2)[CH2:5][CH2:4][CH2:3][CH2:2]1.O.[NH2:20][NH2:21]>C(O)C>[CH:1]1([C:6]2[CH:18]=[CH:17][C:9]([C:10]3[CH2:12][CH2:13][C:14](=[O:15])[NH:20][N:21]=3)=[CH:8][CH:7]=2)[CH2:5][CH2:4][CH2:3][CH2:2]1

Participants

4

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 20352595HCID 20352595, compound

Product 1

HCID 20352614HCID 20352614, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A solution of 3-(p-cyclopentylbenzoyl)propionic acid (4.9 g.) in warm ethanol (50 ml.) was treated with hydrazine hydrate (1.1 g.) and the mixture heated on the steam bath for 1 hour. The colourless crystalline material which separated, was collected and recrystallised from ethanol to yield the product (4.2 g.) in large, colourless needles, m.p. 191°-192°C.

Workup

  1. temperaturethe mixture heated on the steam bath for 1 hour
  2. customThe colourless crystalline material which separated
  3. customwas collected
  4. customrecrystallised from ethanol
  5. customto yield the product (4.2 g.) in large, colourless needles, m.p. 191°-192°C.

Sources & evidence

ORD record
ord-e049182b8fe04467ae62d4a18e5a0120
Source dataset
uspto-grants-1976_08
Patent number
US03975388

Reaction notes

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