Hydrazine hydrate (1:1) → HCID 20352602, compound

HRID 1283401Notes

Reaction equation

HRID 1283401 reaction equation
[NH2:1][C:2]1[CH:3]=[C:4]([CH:12]=[CH:13][C:14]=1[O:15][CH3:16])[C:5]([CH2:7][CH2:8][C:9](O)=[O:10])=O.O.[NH2:18][NH2:19]>>[NH2:1][C:2]1[CH:3]=[C:4]([C:5]2[CH2:7][CH2:8][C:9](=[O:10])[NH:18][N:19]=2)[CH:12]=[CH:13][C:14]=1[O:15][CH3:16]

Participants

3

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 20352627HCID 20352627, compound

Product 1

HCID 20352602HCID 20352602, compoundYield 95%

Procedure

This was prepared in 95% yield by reaction of 3-(3-amino-4-methoxybenzoyl)-propionic acid with hydrazine hydrate in ethanolic solution at reflux temperature for 5 hours. It had m.p. 218°-220°C after crystallisation from ethanol.

Workup

  1. temperatureat reflux temperature for 5 hours
  2. customafter crystallisation from ethanol

Sources & evidence

ORD record
ord-5691397d8f0d470db0321776b9186cfd
Source dataset
uspto-grants-1976_08
Patent number
US03975388

Reaction notes

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