Hydrochloric Acid → HCID 54092612, compound

HRID 1283414Notes

Reaction equation

HRID 1283414 reaction equation
C(CCN1C2C=CC(N)=CC=2C2C1=CC=CC=2)(OC)=O.C(CN)O.Cl.Cl.[OH:27][CH2:28][CH2:29][NH:30][C:31]([CH2:33][CH2:34][N:35]1[C:47]2[CH:46]=[CH:45][C:44]([NH2:48])=[CH:43][C:42]=2[C:41]2[C:36]1=[CH:37][CH:38]=[CH:39][CH:40]=2)=[O:32]>CO>[OH:27][CH2:28][CH2:29][NH:30][C:31]([CH2:33][CH2:34][N:35]1[C:47]2[CH:46]=[CH:45][C:44]([NH2:48])=[CH:43][C:42]=2[C:41]2[C:36]1=[CH:37][CH:38]=[CH:39][CH:40]=2)=[O:32]

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 700EthanolamineHCID 21501772HCID 21501772, compoundHCID 68138067HCID 68138067, compound

Product 1

HCID 54092612HCID 54092612, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

2.68 g. (0.01 mol) 9-(β-carbomethoxyethyl)-3-aminocarbazole (prepared in the manner described in Example 4) were placed in a 50 ml. round-bottomed flask equipped with a condenser and heating bath and heated under reflux with 20 ml. ethanolamine. Thereafter, excess ethanolamine was distilled off under waterpump vacuum and the residue obtained dissolved in methanol. After the addition of methanolic hydrogen chloride, the crystals formed were filtered off with suction and washed with ether. There were obtained 2.44 g. (73.2% of theory) 9-(β-hydroxyethylaminocarbonylethyl)-3-aminocarbazole hydrochloride, which had a melting point of 217°- 218°C.

Workup

  1. customround-bottomed flask equipped with a condenser
  2. temperatureheating bath
  3. temperatureheated
  4. temperatureunder reflux with 20 ml
  5. distillationThereafter, excess ethanolamine was distilled off under waterpump vacuum
  6. customthe residue obtained
  7. customthe crystals formed
  8. filtrationwere filtered off with suction
  9. washwashed with ether
  10. customThere were obtained 2.44 g

Sources & evidence

ORD record
ord-9c0ec4c9863647e6850b053108af4e2d
Source dataset
uspto-grants-1976_08
Patent number
US03975398

Reaction notes

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