Sodium ethoxide → HCID 53683669, compound

HRID 1283454Notes

Reaction equation

HRID 1283454 reaction equation
Cl[C:2]1[C:7]([CH:8](Cl)Cl)=[C:6](Cl)[N:5]=[C:4]([S:12][CH3:13])[N:3]=1.[CH3:14][CH2:15][O-:16].[Na+].[NH:18]1[CH2:23][CH2:22][S:21](=[O:24])[CH2:20][CH2:19]1.C(OCC)(=[O:27])C.O1CCOCC1>>[CH2:15]([O:16][C:6]1[N:5]=[C:4]([S:12][CH3:13])[N:3]=[C:2]([N:18]2[CH2:23][CH2:22][S:21](=[O:24])[CH2:20][CH2:19]2)[C:7]=1[CH:8]=[O:27])[CH3:14]

Participants

5

Reactant 4

HCID 2723922Sodium ethoxideHCID 12600299Thiomorpholine 1-oxideHCID 18422674HCID 18422674, compoundHCID 21517685HCID 21517685, compound

Product 1

HCID 53683669HCID 53683669, compound

Procedure

6-Ethoxy-5-formyl-2-methylthio-4-(1-oxido-thiomorpholino)pyrimidine was prepared in analogous manner from 4,6-dichloro-5-dichloromethyl-2-methylthio-pyrimidine, sodium ethylate and thiomorpholine-1-oxide. M.p. 163°C (ethyl acetate/dioxane).

Sources & evidence

ORD record
ord-4dd9d3fc3301422e9d288314bd71e0aa
Source dataset
uspto-grants-1976_08
Patent number
US03975384

Reaction notes

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