Phosphorus oxychloride → HCID 21517756, compound

HRID 1283455Notes

Reaction equation

HRID 1283455 reaction equation
[C:1]([C:6]1[C:7](O)=[N:8][C:9]([N:12]2[CH2:17][CH2:16][S:15][CH2:14][CH2:13]2)=[N:10][CH:11]=1)([O:3][CH2:4][CH3:5])=[O:2].P(Cl)(Cl)([Cl:21])=O>C(O)C>[C:1]([C:6]1[C:7]([Cl:21])=[N:8][C:9]([N:12]2[CH2:17][CH2:16][S:15][CH2:14][CH2:13]2)=[N:10][CH:11]=1)([O:3][CH2:4][CH3:5])=[O:2]

Participants

4

Reactant 2

HCID 24813Phosphorus oxychlorideHCID 178469816HCID 178469816, compound

Product 1

HCID 21517756HCID 21517756, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

5-Carbethoxy-4-chloro-2-thiomorpholino-pyrimidine was prepared in analogous manner from 5-carbethoxy-4-hydroxy-2-thiomorpholino-pyrimidine and phosphorus oxychloride/phosphoruc pentachloride. M.p. 81°-83°C (ethanol). Preparation of end products of the formula I:

Workup

  1. customPreparation of end products of the formula I

Sources & evidence

ORD record
ord-5ff2806e71094638923eff44eacee778
Source dataset
uspto-grants-1976_08
Patent number
US03975384

Reaction notes

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