Piperazine → HCID 21517701, compound

Participants

Reaction Conditions

Reaction Steps

23 gm (0.07 mol) of 6-ethoxy-2-methylthio-5-nitro-4-thiomorpholino-pyrimidine were added to 68 gm (0.8 mol) of molten piperazine, and the mixture was heated at 110°C for 1 hour. After cooling, ice water was added to the reaction mixture, and the yellow precipitate formed thereby was suction-filtered off, washed with water and recrystallized from isopropanol. Yield: 18 gm (70% of theory); m.p. 166.5°-168.5°C

Provenance & Evidence