Piperazine → HCID 21517701, compound

HRID 1283464Notes

Reaction equation

HRID 1283464 reaction equation
[CH2:1]([O:3][C:4]1[N:9]=[C:8](SC)[N:7]=[C:6]([N:12]2[CH2:17][CH2:16][S:15][CH2:14][CH2:13]2)[C:5]=1[N+:18]([O-:20])=[O:19])[CH3:2].[NH:21]1[CH2:26][CH2:25][NH:24][CH2:23][CH2:22]1>>[CH2:1]([O:3][C:4]1[N:9]=[C:8]([N:21]2[CH2:26][CH2:25][NH:24][CH2:23][CH2:22]2)[N:7]=[C:6]([N:12]2[CH2:17][CH2:16][S:15][CH2:14][CH2:13]2)[C:5]=1[N+:18]([O-:20])=[O:19])[CH3:2]

Participants

3

Reactant 2

HCID 4837PiperazineHCID 21517736HCID 21517736, compound

Product 1

HCID 21517701HCID 21517701, compound

Conditions

Temperature
110 °C

Procedure

23 gm (0.07 mol) of 6-ethoxy-2-methylthio-5-nitro-4-thiomorpholino-pyrimidine were added to 68 gm (0.8 mol) of molten piperazine, and the mixture was heated at 110°C for 1 hour. After cooling, ice water was added to the reaction mixture, and the yellow precipitate formed thereby was suction-filtered off, washed with water and recrystallized from isopropanol. Yield: 18 gm (70% of theory); m.p. 166.5°-168.5°C

Workup

  1. temperatureAfter cooling
  2. customthe yellow precipitate formed
  3. filtrationthereby was suction-filtered off
  4. washwashed with water
  5. customrecrystallized from isopropanol

Sources & evidence

ORD record
ord-c33b74653a1248e0959d81be87c28313
Source dataset
uspto-grants-1976_08
Patent number
US03975384

Reaction notes

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