Piperazine → HCID 54433626, compound

Participants

Reaction Steps

52 gm (0.6 mol) of piperazine were dissolved in 120 ml of boiling dioxane. 61.5 gm (0.18 mol) of 6-ethoxy-2-methylthio-5-nitro-4-(1-oxido-thiomorpholino)-pyrimidine were added over a period of 30 minutes to this solution. After refluxing for 45 minutes, the reaction mixture was poured into 1.5 liters of ice-water, and the yellow precipitate formed thereby was suction-filtered off, washed and recyrstallized from ethanol. Yield: 45.1 gm (65.8% of theory; m.p. 222°-223°C.

Provenance & Evidence