Piperazine → HCID 54433626, compound

HRID 1283465Notes

Reaction equation

HRID 1283465 reaction equation
[NH:1]1[CH2:6][CH2:5][NH:4][CH2:3][CH2:2]1.[CH2:7]([O:9][C:10]1[N:15]=[C:14](SC)[N:13]=[C:12]([N:18]2[CH2:23][CH2:22][S:21](=[O:24])[CH2:20][CH2:19]2)[C:11]=1[N+:25]([O-:27])=[O:26])[CH3:8]>O1CCOCC1>[CH2:7]([O:9][C:10]1[N:15]=[C:14]([N:1]2[CH2:6][CH2:5][NH:4][CH2:3][CH2:2]2)[N:13]=[C:12]([N:18]2[CH2:19][CH2:20][S:21](=[O:24])[CH2:22][CH2:23]2)[C:11]=1[N+:25]([O-:27])=[O:26])[CH3:8]

Participants

4

Reactant 2

HCID 4837PiperazineHCID 54417899HCID 54417899, compound

Product 1

HCID 54433626HCID 54433626, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

52 gm (0.6 mol) of piperazine were dissolved in 120 ml of boiling dioxane. 61.5 gm (0.18 mol) of 6-ethoxy-2-methylthio-5-nitro-4-(1-oxido-thiomorpholino)-pyrimidine were added over a period of 30 minutes to this solution. After refluxing for 45 minutes, the reaction mixture was poured into 1.5 liters of ice-water, and the yellow precipitate formed thereby was suction-filtered off, washed and recyrstallized from ethanol. Yield: 45.1 gm (65.8% of theory; m.p. 222°-223°C.

Workup

  1. temperatureAfter refluxing for 45 minutes
  2. customthe yellow precipitate formed
  3. filtrationthereby was suction-filtered off
  4. washwashed

Sources & evidence

ORD record
ord-9b9284d452634db4837fed48b00707b7
Source dataset
uspto-grants-1976_08
Patent number
US03975384

Reaction notes

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