Water → HCID 54433626, compound

HRID 1283467Notes

Reaction equation

HRID 1283467 reaction equation
[CH2:1]([O:3][C:4]1[N:9]=[C:8](Cl)[N:7]=[C:6]([N:11]2[CH2:16][CH2:15][S:14](=[O:17])[CH2:13][CH2:12]2)[C:5]=1[N+:18]([O-:20])=[O:19])[CH3:2].[NH:21]1[CH2:26][CH2:25][NH:24][CH2:23][CH2:22]1.O>C(O)C>[CH2:1]([O:3][C:4]1[N:9]=[C:8]([N:21]2[CH2:26][CH2:25][NH:24][CH2:23][CH2:22]2)[N:7]=[C:6]([N:11]2[CH2:16][CH2:15][S:14](=[O:17])[CH2:13][CH2:12]2)[C:5]=1[N+:18]([O-:20])=[O:19])[CH3:2]

Participants

5

Reactant 3

HCID 962WaterHCID 4837PiperazineHCID 54192897HCID 54192897, compound

Product 1

HCID 54433626HCID 54433626, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

12 gm (0.037 mol) of 6-ethoxy-2-chloro-5-nitro-4-(1-oxido-thiomorpholino)-pyrimidine were stirred together with 22 gm (0.28 mol) of piperazine in ethanol at 40°C for 2 hours. Then, the reaction mixture was poured into water, and the precipitate formed thereby was suction-filtered off and recrystallized from ethanol. Yield: 13 gm (93.8% of theory); m.p. 223°-224°C.

Workup

  1. customthe precipitate formed
  2. filtrationthereby was suction-filtered off
  3. customrecrystallized from ethanol

Sources & evidence

ORD record
ord-9737e74c9299417eb477c38e7c74fffa
Source dataset
uspto-grants-1976_08
Patent number
US03975384

Reaction notes

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