Piperazine → HCID 54433626, compound

HRID 1283469Notes

Reaction equation

HRID 1283469 reaction equation
C(O[C:4]1[N:9]=[C:8]([N:10]2[CH2:15][CH2:14][S:13](=[O:16])[CH2:12][CH2:11]2)[C:7]([N+:17]([O-:19])=[O:18])=[C:6]([O:20][CH2:21][CH3:22])[N:5]=1)C.[NH:23]1[CH2:28][CH2:27][NH:26][CH2:25][CH2:24]1>>[CH2:21]([O:20][C:6]1[N:5]=[C:4]([N:23]2[CH2:28][CH2:27][NH:26][CH2:25][CH2:24]2)[N:9]=[C:8]([N:10]2[CH2:11][CH2:12][S:13](=[O:16])[CH2:14][CH2:15]2)[C:7]=1[N+:17]([O-:19])=[O:18])[CH3:22]

Participants

3

Reactant 2

HCID 4837PiperazineHCID 21517759HCID 21517759, compound

Product 1

HCID 54433626HCID 54433626, compound

Procedure

2 gm (6 millimols) of 2,6-di-ethoxy-5-nitro-4-(1-oxido-thiomorpholino)-pyrimidine (m.p. 130°-132°C) were heated together with 8.6 gm (100 millimols) of piperazine at 125°C for 4 hours. The reaction mixture was then poured over ice, and the crystals formed thereby were suction-filtered off and recrystallized from ethanol. Yield: 0.53 gm (23.6% of theory); m.p. 221°-222°C.

Workup

  1. additionThe reaction mixture was then poured over ice
  2. customthe crystals formed
  3. filtrationthereby were suction-filtered off
  4. customrecrystallized from ethanol

Sources & evidence

ORD record
ord-21546bee12f441a5a263d79b76863999
Source dataset
uspto-grants-1976_08
Patent number
US03975384

Reaction notes

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