Water → HCID 54433626, compound

HRID 1283472Notes

Reaction equation

HRID 1283472 reaction equation
[CH2:1]([O:3][C:4]1[N:9]=[C:8]([N:10]2[CH2:15][CH2:14][N:13](C=O)[CH2:12][CH2:11]2)[N:7]=[C:6]([N:18]2[CH2:23][CH2:22][S:21](=[O:24])[CH2:20][CH2:19]2)[C:5]=1[N+:25]([O-:27])=[O:26])[CH3:2].[OH-].[Na+].O>CO>[CH2:1]([O:3][C:4]1[N:9]=[C:8]([N:10]2[CH2:11][CH2:12][NH:13][CH2:14][CH2:15]2)[N:7]=[C:6]([N:18]2[CH2:19][CH2:20][S:21](=[O:24])[CH2:22][CH2:23]2)[C:5]=1[N+:25]([O-:27])=[O:26])[CH3:2]

Participants

5

Reactant 3

HCID 962WaterHCID 14798Sodium HydroxideHCID 86733828HCID 86733828, compound

Product 1

HCID 54433626HCID 54433626, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

1.2 gm (3 millimols) of 6-ethoxy-2-(N-formyl-piperazino)-5-nitro-4-(1-oxido-thiomorpholino)-pyrimidine (m.p. 209°-211°C) were refluxed together with 1.2 gm (30 millimols) of sodium hydroxide in 80 ml of methanol for 3 hours. The reaction mixture was then poured into water, and the aqueous mixture was extracted with chloroform. The chloroform phase was dried with sodium sulfate, and the chloroform was removed in vacuo. Yield: 1 gm (89.6% of theory), m.p. 222°-223°C (ethanol).

Workup

  1. extractionthe aqueous mixture was extracted with chloroform
  2. dry with materialThe chloroform phase was dried with sodium sulfate
  3. customthe chloroform was removed in vacuo

Sources & evidence

ORD record
ord-43bf46853c55400e90e7016f975a218c
Source dataset
uspto-grants-1976_08
Patent number
US03975384

Reaction notes

Loading…