Water → HCID 54433626, compound

Participants

Reaction Steps

1.2 gm (3 millimols) of 6-ethoxy-2-(N-formyl-piperazino)-5-nitro-4-(1-oxido-thiomorpholino)-pyrimidine (m.p. 209°-211°C) were refluxed together with 1.2 gm (30 millimols) of sodium hydroxide in 80 ml of methanol for 3 hours. The reaction mixture was then poured into water, and the aqueous mixture was extracted with chloroform. The chloroform phase was dried with sodium sulfate, and the chloroform was removed in vacuo. Yield: 1 gm (89.6% of theory), m.p. 222°-223°C (ethanol).

Provenance & Evidence