Pyridine → HCID 131710433, compound

HRID 1283532Notes

Reaction equation

HRID 1283532 reaction equation
N[CH2:2][C:3]1([N:9]2[CH2:14][CH2:13][CH2:12][CH2:11][CH2:10]2)[CH2:8][CH2:7][CH2:6][CH2:5][CH2:4]1.[F:15][C:16]1[CH:24]=[CH:23][C:19]([C:20]([Cl:22])=[O:21])=[CH:18][CH:17]=1.[N:25]1C=CC=CC=1>>[ClH:22].[F:15][C:16]1[CH:24]=[CH:23][C:19]([C:20]([NH:25][CH:8]2[CH2:7][CH2:6][CH2:5][CH2:4][C:3]2([CH3:2])[N:9]2[CH2:10][CH2:11][CH2:12][CH2:13][CH2:14]2)=[O:21])=[CH:18][CH:17]=1

Participants

4

Reactant 3

HCID 1049PyridineHCID 678794-Fluorobenzoyl chlorideHCID 3984021-[1-(Piperidin-1-yl)cyclohexyl]methanamine

Product 1

HCID 131710433HCID 131710433, compound

Procedure

A mixture of 1-(1-aminomethylcyclohexyl) piperidine (1.5 g.), 4-fluorobenzoyl chloride (2 ml) and pyridine (10 ml) was allowed to stand at room temperature for 1 hr. The crystalline material produced was filtered (2.35 g. 86.6%) and afforded pale lemon rosettes of 1-(4-fluorobenzamido-methylcyclohexyl)piperidine, hydrochloride m.p. 243°-5° (Decomp.).

Workup

  1. customThe crystalline material produced
  2. filtrationwas filtered (2.35 g. 86.6%)

Sources & evidence

ORD record
ord-56fbb9716c8b4366a2084391f6ebe297
Source dataset
uspto-grants-1976_08
Patent number
US03975443

Reaction notes

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