反应详情

A solution of N-[2-methylamino-2-methyl propyl]benzamide (1 g., 0.0052 mole) in MEK (50 ml.) was added to a solution of cyclopropyl carbinol bromide (0.66 g.,) in MEK (30 ml.) containing sodium carbonate (0.55 g.,) and a few crystals of sodium iodide. The mixture was refluxed for 24 hrs. and then filtered and the excess MEK evaporated under reduced pressure to give a liquid residue. This was passed down an alumina column, eluting with ethyl acetate to give N-[2-[(cyclopropylmethyl)methylamino]-2-methylpropyl]benzamide (0.9 g.).

1. temperatureThe mixture was refluxed for 24 hrs
2. filtrationand then filtered
3. customthe excess MEK evaporated under reduced pressure
4. customto give a liquid residue
5. washeluting with ethyl acetate