反应详情

A solution of N-[2-methylamino-2-methylpropyl]benzamide (1. g.,) in MEK (25 ml.) was added to a solution of allyl bromide (0.58 g.,) in MEK (25 ml.) containing sodium carbonate (0.55 g.,) and a few crystals of sodium iodide. The mixture was refluxed for 24 hrs. The inorganic solids were filtered off and the filtrant concentrated by evaporation under reduced pressure. The liquid residue was eluted down an alumina column with ethyl acetate to give N-[2-(allylmethylamino)-2-methylpropyl]benzamide 1.1 g.

1. temperatureThe mixture was refluxed for 24 hrs
2. filtrationThe inorganic solids were filtered off
3. concentrationthe filtrant concentrated by evaporation under reduced pressure
4. washThe liquid residue was eluted down an alumina column with ethyl acetate