Thiomorpholine → HCID 21518493, compound

HRID 1283582Notes

Reaction equation

HRID 1283582 reaction equation
[S:1]1[CH2:6][CH2:5][N:4]([C:7]2[C:16]3[C:11](=[C:12]([N+]([O-])=O)[CH:13]=[CH:14][CH:15]=3)[CH:10]=[C:9]([Cl:20])[N:8]=2)[CH2:3][CH2:2]1.Cl[C:22]1C2C(=C([N+]([O-])=O)C=CC=2)C=C(Cl)N=1.N1CCSCC1>C(OCC)(=O)C>[S:1]1[CH2:6][CH2:5][N:4]([C:7]2[C:16]3[C:11](=[C:12]([CH3:22])[CH:13]=[CH:14][CH:15]=3)[CH:10]=[C:9]([Cl:20])[N:8]=2)[CH2:3][CH2:2]1

Participants

5

Reactant 3

HCID 67164ThiomorpholineHCID 21518467HCID 21518467, compoundHCID 21518483HCID 21518483, compound

Product 1

HCID 21518493HCID 21518493, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

1-Thiomorpholino-3-chloro-5-nitro-isoquinoline, m.p. 163°-165°C (from ethyl acetate), was prepared from 1,3-dichloro-5-nitro-isoquinoline [see M. D. Nair and S. R. Mehta, Indian J. Chem. 5, 403 (1967); m.p. 176°-177°C] and thiomorpholine.

Sources & evidence

ORD record
ord-2649d48bc472462687a156b4b9b43057
Source dataset
uspto-grants-1976_08
Patent number
US03975524

Reaction notes

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