HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → HCID 21518479, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Piperazine | HCID 4837 | — |
| Reactant | HCID 21518491 | HCID 21518491 | — |
| Solvent | Diphenyl Ether | HCID 7583 | — |
| Product | HCID 21518479 | HCID 21518479 | 41% |
Reaction Steps
1-Thiomorpholino-3-piperazino-5-methoxy-isoquinoline was prepared analogous to Example 3 from 1-thiomorpholino-3-chloro-5-methoxy-isoquinoline by heating for 50 hours with piperazine at 190°C in diphenyl ether. M.p. of the hemisulfate: 282°-284°C (decomp., from water). Yield: 41% of theory.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US03975524 |
| Source dataset | uspto-grants-1976_08 |
| ORD ID | ord-e03fbfb267c5413ba3f38ba5555d82b3 |
| Source note | uspto-grants-1976_08 |