Water → HCID 21518479, compound

HRID 1283587Notes

Reaction equation

HRID 1283587 reaction equation
[S:1]1[CH2:6][CH2:5][N:4]([C:7]2[C:16]3[C:11](=[C:12]([O:17][CH3:18])[CH:13]=[CH:14][CH:15]=3)[CH:10]=[C:9](Cl)[N:8]=2)[CH2:3][CH2:2]1.[NH:20]1[CH2:25][CH2:24][NH:23][CH2:22][CH2:21]1.O>C1(OC2C=CC=CC=2)C=CC=CC=1>[S:1]1[CH2:6][CH2:5][N:4]([C:7]2[C:16]3[C:11](=[C:12]([O:17][CH3:18])[CH:13]=[CH:14][CH:15]=3)[CH:10]=[C:9]([N:20]3[CH2:25][CH2:24][NH:23][CH2:22][CH2:21]3)[N:8]=2)[CH2:3][CH2:2]1

Participants

5

Reactant 3

HCID 962WaterHCID 4837PiperazineHCID 21518491HCID 21518491, compound

Product 1

HCID 21518479HCID 21518479, compoundYield 41%

Reagents, catalysts & solvents 1

HCID 7583Diphenyl EtherSolvent

Procedure

1-Thiomorpholino-3-piperazino-5-methoxy-isoquinoline was prepared analogous to Example 3 from 1-thiomorpholino-3-chloro-5-methoxy-isoquinoline by heating for 50 hours with piperazine at 190°C in diphenyl ether. M.p. of the hemisulfate: 282°-284°C (decomp., from water). Yield: 41% of theory.

Sources & evidence

ORD record
ord-e03fbfb267c5413ba3f38ba5555d82b3
Source dataset
uspto-grants-1976_08
Patent number
US03975524

Reaction notes

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