Nicotinic Acid → 3-Pyridinecarbonyl chloride, hydrochloride (1:1)

HRID 1283615Notes

Reaction equation

HRID 1283615 reaction equation
[C:1]([OH:9])(=O)[C:2]1[CH:7]=[CH:6][CH:5]=[N:4][CH:3]=1.S(Cl)([Cl:12])=O>>[ClH:12].[C:1]([Cl:12])(=[O:9])[C:2]1[CH:7]=[CH:6][CH:5]=[N:4][CH:3]=1

Participants

3

Reactant 2

HCID 938Nicotinic AcidHCID 24386Thionyl Chloride

Product 1

HCID 884383-Pyridinecarbonyl chloride, hydrochloride (1:1)

Conditions

Temperature
60 °C

Procedure

A mixture of 90 grams of nicotinic acid and 180 ml of thionyl chloride was heated at 55 to 65°C. for 31/2 hours. The excess thionyl chloride was removed in vacuum and the nicotinoyl chloride-hydrochloride reaction product can be used without further purification.

Workup

  1. customThe excess thionyl chloride was removed in vacuum
  2. customthe nicotinoyl chloride-hydrochloride reaction product
  3. customcan be used without further purification

Sources & evidence

ORD record
ord-f6f314e6b4ac490a928018abca221f50
Source dataset
uspto-grants-1976_08
Patent number
US03975532

Reaction notes

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