4-Benzoyl-3-(methylsulfanyl)-1,3-dihydro-2H-indol-2-one → 4-Benzoyl-1,3-dihydro-2H-indol-2-one

HRID 1283625노트

반응식

HRID 1283625 반응식
[C:1]([C:9]1[CH:17]=[CH:16][CH:15]=[C:14]2[C:10]=1[CH:11](SC)[C:12](=[O:18])[NH:13]2)(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1>[Ni].O1CCCC1>[C:1]([C:9]1[CH:17]=[CH:16][CH:15]=[C:14]2[C:10]=1[CH2:11][C:12](=[O:18])[NH:13]2)(=[O:8])[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

참가 물질

4

반응물 1

HCID 129235524-Benzoyl-3-(methylsulfanyl)-1,3-dihydro-2H-indol-2-one

생성물 1

HCID 129012464-Benzoyl-1,3-dihydro-2H-indol-2-one

시약·촉매·용매 2

HCID 935Nickel촉매HCID 8028Tetrahydrofuran용매

실험 절차

A stirred suspension of 7.0 g. (0.0248 mole) of 4-benzoyl-3-methylthioindolin-2-one in 400 ml. of tetrahydrofuran was treated portionwise under a nitrogen atmosphere with 35.0 g. of Raney nickel over a 2.5 hr. period. The reaction mixture was stirred for 1.5 hr. after addition was complete and the catalyst removed by filtration. The filter cake was washed well with tetrahydrofuran and methylene chloride and the filtrate evaporated under reduced pressure. The residue (5.6 g.) was recrystallized from methanol and gave 4.45 g. (76%) of product m.p. 210°-212°C.

후처리

  1. additionA stirred suspension of 7.0 g
  2. additionafter addition
  3. customthe catalyst removed by filtration
  4. washThe filter cake was washed well with tetrahydrofuran and methylene chloride
  5. customthe filtrate evaporated under reduced pressure
  6. customThe residue (5.6 g.) was recrystallized from methanol
  7. customgave 4.45 g

출처 및 근거

ORD 기록
ord-e38bbb3b10204703a8f0fa747b541232
출처 데이터셋
uspto-grants-1976_08
특허 번호
US03975531

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