Aluminium lithium hydride → HCID 21516433, compound

HRID 1283727Notes

Reaction equation

HRID 1283727 reaction equation
[H-].[Al+3].[Li+].[H-].[H-].[H-].[CH2:7]([CH2:14][NH:15][CH:16]1[C:24]2[C:19](=[CH:20][CH:21]=[CH:22][CH:23]=2)[C:18](=[O:25])[CH:17]1[CH3:26])[C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1>O1CCCC1>[CH2:7]([CH2:14][NH:15][CH:16]1[C:24]2[C:19](=[CH:20][CH:21]=[CH:22][CH:23]=2)[CH:18]([OH:25])[CH:17]1[CH3:26])[C:8]1[CH:9]=[CH:10][CH:11]=[CH:12][CH:13]=1

Participants

4

Reactant 2

HCID 21226445Aluminium lithium hydrideHCID 21516429HCID 21516429, compound

Product 1

HCID 21516433HCID 21516433, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent2×

Procedure

An ice-cold suspension of 1.5 grams (0.040 mole) of lithium aluminum hydride in 35 ml of dry tetrahydrofuran is treated dropwise over a period of about 30 minutes with a solution of 10.4 grams (0.039 mole) of 3-benzylmethylamino-2-methylindan-1-one in 80 ml of tetrahydrofuran. The mixture is stirred at 0° for 4 hours and then quenched by the addition of ethylacetate, 2N sodium hydroxide and water. The solids are filtered, and the filtrate is dried over magnesium sulfate, filtered and evaporated to yield 3-benzylmethylamino-2-methylindan-1-ol as an oil.

Workup

  1. customquenched by the addition of ethylacetate, 2N sodium hydroxide and water
  2. filtrationThe solids are filtered
  3. dry with materialthe filtrate is dried over magnesium sulfate
  4. filtrationfiltered
  5. customevaporated

Sources & evidence

ORD record
ord-f790f0653b404d558d84ce9d0edf017b
Source dataset
uspto-grants-1976_08
Patent number
US03976634

Reaction notes

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