Ammonia → HCID 15075950, compound

Participants

Reaction Steps

The nitrile of Example 1 (1.57 g.) was reduced at 40 p.s.i. and 40°C in the presence of Raney Nickel W2 (2.g.) in absolute ethanol half saturated with dry ammonia (50 ml.). Uptake ceased when slightly more than 2 equivalents of hydrogen had been taken up. The catalyst was filtered off, the ethanol solution evaporated to leave a green oil which gave 1.22 g. microcrystals, m.p. 250°-252°(decomp), of 1-(3-aminopropyl)- 3-(m-chlorophenyl)- 3-hydroxyindolin-2-one hydrochloride on treatment with isopropanol and hydrogen chloride in dry ether.

Provenance & Evidence