反应详情

A solution of t-amyl chloroformate (0.05 mol) in an ether-toluene mixture (30 ml) is cooled to -10°C, and a solution of ethyl 2-hydroxyimino-2-cyanoacetate (7.2 g) and triethylamine (7.0 ml) in dry benzene (50 ml) is dropwise added thereto. The resulting mixture is allowed to stand at room temperature over night. The reaction mixture is admixed with water and filtered. The organic layer is separated, washed with water, dried and concentrated to give ethyl 2-t-amyloxycarbonyloxyimino-2-cyanoacetate (5.1 g) as an oil.

1. waitto stand at room temperature over night
2. filtrationfiltered
3. customThe organic layer is separated
4. washwashed with water
5. customdried
6. concentrationconcentrated