反应详情

To a suspension of 4'-amino-2'-bromo-6'-trifluoromethylacetanilide sulfate is added two molar equivalents of ethyl nitrite. The reaction mixture is cooled (0°) and stirred for 2 hours then allowed to warm to 25° and a catalytic amount of copper bronze is added. The mixture is stirred for 3 hours with the temperature maintained below 40°. The mixture is then refluxed briefly and cooled. Addition of water gives 2'-bromo-6'-trifluoromethylacetanilide which is collected by filtration.

1. temperatureThe reaction mixture is cooled (0°)
2. temperatureto warm to 25°
3. stirringThe mixture is stirred for 3 hours with the temperature
4. temperaturemaintained below 40°
5. temperatureThe mixture is then refluxed briefly
6. temperaturecooled