Ethyl Nitrite → 2'-Bromo-6'-trifluoromethylacetanilide

Participants

Reaction Steps

To a suspension of 4'-amino-2'-bromo-6'-trifluoromethylacetanilide sulfate is added two molar equivalents of ethyl nitrite. The reaction mixture is cooled (0°) and stirred for 2 hours then allowed to warm to 25° and a catalytic amount of copper bronze is added. The mixture is stirred for 3 hours with the temperature maintained below 40°. The mixture is then refluxed briefly and cooled. Addition of water gives 2'-bromo-6'-trifluoromethylacetanilide which is collected by filtration.

Provenance & Evidence