Water → 2-Bromo-6-(trifluoromethyl)aniline

HRID 1283787Notes

Reaction equation

HRID 1283787 reaction equation
[Br:1][C:2]1[CH:11]=[CH:10][CH:9]=[C:8]([C:12]([F:15])([F:14])[F:13])[C:3]=1[NH:4]C(=O)C.O>S(=O)(=O)(O)O>[Br:1][C:2]1[CH:11]=[CH:10][CH:9]=[C:8]([C:12]([F:13])([F:15])[F:14])[C:3]=1[NH2:4]

Participants

4

Reactant 2

HCID 962WaterHCID 232538532'-Bromo-6'-trifluoromethylacetanilide

Product 1

HCID 940592-Bromo-6-(trifluoromethyl)aniline

Reagents, catalysts & solvents 1

HCID 1118Sulfuric AcidSolvent

Procedure

2'-Bromo-6'-trifluoromethylacetanilide in 50% aqueous sulfuric acid is warmed on a steam bath for 2 hours, then refluxed for 1 hour. Cooling and dilution with water gives 2-bromo-6-trifluoromethylaniline.

Workup

  1. temperaturerefluxed for 1 hour
  2. temperatureCooling

Sources & evidence

ORD record
ord-30256f537cbf4c6fb992bba3912c1689
Source dataset
uspto-grants-1976_08
Patent number
US03976633

Reaction notes

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