反应详情

A solution of 1.99 g. (0.01 mol.) of 2-[(hexyloxy)-carbonyl]pyrrolidine obtained in Example 1, 3.45 g. (0.01 mol.) of benzyl 7-iodoheptanoate and 1.21 g. (0.012 mol.) of triethylamine in 10 ml. of benzene is heated at 50° for 16 hours. The cooled reaction mixture is washed with 5% aqueous sodium bicarbonate, saturated aqueous chloride, dried, and concentrated in vacuo to give an oil, 2-[(hexyloxy)carbonyl]-1-pyrrolidineheptanoic acid benzyl ester.

1. customThe cooled reaction mixture
2. washis washed with 5% aqueous sodium bicarbonate, saturated aqueous chloride
3. customdried
4. concentrationconcentrated in vacuo