Methylamine → HCID 13336925, compound

HRID 128387Notes

Reaction equation

HRID 128387 reaction equation
[C:1]([C:3]1[C:8]([C:9]#[N:10])=[N:7][C:6](Cl)=[C:5]([CH2:12][CH2:13][CH2:14][CH3:15])[N:4]=1)#[N:2].[CH3:16][NH2:17]>C1C=CC=CC=1>[C:1]([C:3]1[C:8]([C:9]#[N:10])=[N:7][C:6]([NH:17][CH3:16])=[C:5]([CH2:12][CH2:13][CH2:14][CH3:15])[N:4]=1)#[N:2]

Participants

4

Reactant 2

HCID 6329MethylamineHCID 129072015-Butyl-6-chloropyrazine-2,3-dicarbonitrile

Product 1

HCID 13336925HCID 13336925, compoundYield 81%

Reagents, catalysts & solvents 1

HCID 241BenzeneSolvent

Conditions

Temperature
30 °C

Procedure

2,3-Dicyano-5-chloro-6-n-butylpyrazine (2.21 g; 0.01 mole) was dissolved in 30 ml of benzene, and with stirring at 30° C., 1.55 g (0.02 mole) of a 40% aqueous solution of methylamine was added. Then, the mixture was stirred at 30° to 40° C. for 2 hours. The reaction mixture was worked up in the same way as in Example 13 to afford 1.75 g (yield 81%) of 2,3-dicyano-5-methylamino-6-n-butylpyrazine.

Workup

  1. stirringThen, the mixture was stirred at 30° to 40° C. for 2 hours

Sources & evidence

ORD record
ord-05909422733d4b4a812b5d1dd32268a1
Source dataset
uspto-grants-1981_03
Patent number
US04259489

Reaction notes

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