Diethylamine → HCID 13336936, compound

HRID 128389Notes

Reaction equation

HRID 128389 reaction equation
[C:1]([C:3]1[C:8]([C:9]#[N:10])=[N:7][C:6](Cl)=[C:5]([CH2:12][C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)[N:4]=1)#[N:2].[CH2:19]([NH:21][CH2:22][CH3:23])[CH3:20]>C1C=CC=CC=1>[C:1]([C:3]1[C:8]([C:9]#[N:10])=[N:7][C:6]([N:21]([CH2:22][CH3:23])[CH2:19][CH3:20])=[C:5]([CH2:12][C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)[N:4]=1)#[N:2]

Participants

4

Reactant 2

HCID 8021DiethylamineHCID 13336835HCID 13336835, compound

Product 1

HCID 13336936HCID 13336936, compoundYield 75.5%

Reagents, catalysts & solvents 1

HCID 241BenzeneSolvent

Procedure

2,3-Dicyano-5-chloro-6-benzylpyrazine (1.27 g; 0.005 mole) was dissolved in 30 ml of benzene, and the solution was cooled to 5° to 10° C. With stirring, the mixture was worked up in the same way as in Example 13 using 0.80 g (0.01 mole) of diethylamine. Recrystallization from ethanol afforded 1.10 g (yield 75%) of 2,3-dicyano-5-diethylamino-6-benzylpyrazine.

Workup

  1. temperaturethe solution was cooled to 5° to 10° C
  2. customRecrystallization from ethanol

Sources & evidence

ORD record
ord-db18c81956fb441c807685d2d6395926
Source dataset
uspto-grants-1981_03
Patent number
US04259489

Reaction notes

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