Benzene → HCID 568965, compound

HRID 1283928Notes

Reaction equation

HRID 1283928 reaction equation
[H-].[Na+].C1C=CC=CC=1.[CH2:9]([OH:11])[CH3:10].[C:12]1([CH2:22][C:23]([OH:25])=O)[CH:17]=[CH:16][CH:15]=[CH:14][C:13]=1[CH2:18][C:19]([OH:21])=O>O>[CH2:9]([O:11][C:19]([CH:18]1[C:13]2[C:12](=[CH:17][CH:16]=[CH:15][CH:14]=2)[CH2:22][C:23]1=[O:25])=[O:21])[CH3:10]

Participants

6

Reactant 4

HCID 241Benzene2×HCID 702EthanolHCID 24123o-Phenylenediacetic acidHCID 24758Sodium hydride

Product 1

HCID 568965HCID 568965, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

To a stirred mixture of sodium hydride (126 g. of a 57% suspension in nujol), 2000 ml. of benzene and 2 ml. of ethanol heated at its reflux temperature under dry nitrogen is added dropwise the diethyl ester of o-phenylene-diacetic acid (335.6 g.) in 700 ml. of benzene. The mixture is refluxed 1.5 hours, poured into water and extracted with ether. The ether extracts are dried and concentrated to give an oil which is crystallized from ethanol-water to give 220 g. of the title product withm m.p. 58°-61°.

Workup

  1. temperaturereflux temperature under dry nitrogen
  2. temperatureThe mixture is refluxed 1.5 hours
  3. extractionextracted with ether
  4. dry with materialThe ether extracts are dried
  5. concentrationconcentrated
  6. customto give an oil which
  7. customis crystallized from ethanol-water
  8. customto give 220 g

Sources & evidence

ORD record
ord-da253c0520654a5ab2019ac0c3bc9d87
Source dataset
uspto-grants-1976_08
Patent number
US03976696

Reaction notes

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