反应详情

A mixture of 5.16 g of ethylene urea and 90 g of N,N-diethyl-sulphamoyl-chloride is heated at 110° for 3 hours. The reaction mixture is cooled and triturated with 300 ml of methanol, filtered and the filtrate evaporated off to dryness and the residue dissolved in 5% methanol in chloroform and chromatographed on a column of silica gel. That fraction which elutes with 5% methanol in chloroform is recrystallized from a mixture of methylenechlorid and hexane to give 1-(N,N-diethylsulphamoyl)--2-oxo-tetrahydroimidazole which melts at 80°-82°.

1. temperatureis heated at 110° for 3 hours
2. temperatureThe reaction mixture is cooled
3. customtriturated with 300 ml of methanol
4. filtrationfiltered
5. customthe filtrate evaporated off to dryness
6. dissolutionthe residue dissolved in 5% methanol in chloroform
7. customchromatographed on a column of silica gel
8. customis recrystallized from a mixture of methylenechlorid and hexane