Methyl isothiocyanate → 4-Cyclohexyl 2-methylthiocarbamoyl 1-morpholyl cyclohex-1 ene

HRID 1284011Notes

Reaction equation

HRID 1284011 reaction equation
[CH3:1][N:2]=[C:3]=[S:4].[CH:5]1([CH:11]2[CH2:16][CH2:15][C:14]([N:17]3[CH2:22][CH2:21][O:20][CH2:19][CH2:18]3)=[CH:13][CH2:12]2)[CH2:10][CH2:9][CH2:8][CH2:7][CH2:6]1>CCCCCCC>[CH:5]1([CH:11]2[CH2:16][CH2:15][C:14]([N:17]3[CH2:18][CH2:19][O:20][CH2:21][CH2:22]3)=[C:13]([C:3](=[S:4])[NH:2][CH3:1])[CH2:12]2)[CH2:6][CH2:7][CH2:8][CH2:9][CH2:10]1

Participants

4

Reactant 2

HCID 11167Methyl isothiocyanateHCID 215152864-Cyclohexyl 1-morpholyl cyclohex-1 ene

Product 1

HCID 215153064-Cyclohexyl 2-methylthiocarbamoyl 1-morpholyl cyclohex-1 ene

Reagents, catalysts & solvents 1

HCID 8900HeptaneSolvent2×

Procedure

In a three-neck flask there are introduced successively 2.04 g of methyl isothiocyanate, 20 ml heptane and, over the course of 5 minutes, a solution of 7.1 g 4-cyclohexyl-1-morpholyl-cyclohex-1-ene in 80 ml heptane and the reaction mixture is kept under vigourous stirring for 18 hours at room temperature.

Workup

  1. customover the course of 5 minutes

Sources & evidence

ORD record
ord-cdb1f53495af4930bd33e4596de6e3f9
Source dataset
uspto-grants-1976_08
Patent number
US03978044

Reaction notes

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