Allylhydrazine → 5-Cyclohexyl 3-phenylamino 2-methyl 4,5,6,7-tetrahydroindazole

HRID 1284015Notes

Reaction equation

HRID 1284015 reaction equation
C1(C2CCC(=O)C(C(=S)NC3C=CC=CC=3)C2)CCCCC1.C(NN)C#C.[CH:28]1([CH:34]2[CH2:42][CH2:41][C:40]3[C:36](=[C:37]([NH:46][C:47]4[CH:52]=[CH:51][CH:50]=[CH:49][CH:48]=4)[N:38]([C:43]#CC)[N:39]=3)[CH2:35]2)[CH2:33][CH2:32][CH2:31][CH2:30][CH2:29]1.C(NN)C=C.C1(C2CCC3C(=C(NC4C=CC=CC=4)N(C=CC)N=3)C2)CCCCC1>>[CH:28]1([CH:34]2[CH2:42][CH2:41][C:40]3[C:36](=[C:37]([NH:46][C:47]4[CH:48]=[CH:49][CH:50]=[CH:51][CH:52]=4)[N:38]([CH3:43])[N:39]=3)[CH2:35]2)[CH2:29][CH2:30][CH2:31][CH2:32][CH2:33]1

Participants

6

Reactant 5

HCID 81921AllylhydrazineHCID 15567523(Prop-2-yn-1-yl)hydrazineHCID 215152964-Cyclohexyl 2-phenylthiocarbamoyl cyclohexanone2×HCID 867338765-Cyclohexyl 3-phenylamino 2-propynyl 4,5,6,7-tetrahydroindazoleHCID 867338775-Cyclohexyl 3-phenylamino 2-propenyl 4,5,6,7-tetrahydro indazole

Product 1

HCID 215152905-Cyclohexyl 3-phenylamino 2-methyl 4,5,6,7-tetrahydroindazole

Procedure

In a similar manner starting from 6.9 g of 4-cyclohexyl 2-phenylthiocarbamoyl cyclohexanone and from 1.68 g propargylhydrazine, 4.10 g of 5-cyclohexyl 3-phenylamino 2-propynyl 4,5,6,7-tetrahydroindazole are obtained. In a similar manner starting from 6.9 g 4-cyclohexyl 2-phenylthiocarbamoyl cyclohexanone and 1.70 g allylhydrazine, 5.4 g of 5-cyclohexyl 3-phenylamino 2-propenyl 4,5,6,7-tetrahydro indazole are obtained.

Workup

  1. customare obtained
  2. customare obtained

Sources & evidence

ORD record
ord-870667a1928e475c8401cd45bea106d0
Source dataset
uspto-grants-1976_08
Patent number
US03978044

Reaction notes

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