HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydroxyamine hydrochloride → 3-Formylindole-4-carboxylic acid methyl ester oxime
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydroxyamine hydrochloride | HCID 443297 | — |
| Reactant | Sodium Acetate | HCID 517045 | — |
| Reactant | methyl 3-formyl-1H-indole-4-carboxylate | HCID 12396096 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 3-Formylindole-4-carboxylic acid methyl ester oxime | HCID 86733222 | — |
Reaction Steps
A mixture of 3-formyl-4-indolecarboxylic acid methyl ester (2.03 g), described in Example 1, 10 ml of a 5M aqueous solution of hydroxylamine hydrochloride, 10 ml of 5M aqueous sodium acetate and 20 ml of methanol is stirred at 45° - 55°C for 1 hour. The precipitate is collected and washed with cold water. Recrystallization from methanol-water gives the title compound, mp 178° - 179°C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US03978066 |
| Source dataset | uspto-grants-1976_08 |
| ORD ID | ord-c7c5ca2d2b964d6ea1e413c5f9c25fcc |
| Source note | uspto-grants-1976_08 |