反应详情

A mixture of 3-formyl-4-indolecarboxylic acid methyl ester (2.03 g), described in Example 1, 10 ml of a 5M aqueous solution of hydroxylamine hydrochloride, 10 ml of 5M aqueous sodium acetate and 20 ml of methanol is stirred at 45° - 55°C for 1 hour. The precipitate is collected and washed with cold water. Recrystallization from methanol-water gives the title compound, mp 178° - 179°C.

1. customThe precipitate is collected
2. washwashed with cold water
3. customRecrystallization from methanol-water