反应详情

A mixture of 47 g of ethyl 2-[4-(chloroacetyl)phenyl]propionate, 100 ml of ethanol and 30 g of 2-aminopyridine is heated under reflux for 2 hours. The ethanol is distilled off under reduced pressure, and water is added to the residue. The mixture is extracted with benzene, and the extract is washed with water, dried and concentrated to give a reddish brown oil. To the oil is added isopropyl ether, and the crystalline precipitate is filtered off and recrystallized from isopropyl ether to give 22 g of ethyl 2-[4-(imidazo[1,2-a]pyridin-2-yl)phenyl]propionate as colorless scales melting at 110°-112°C.

1. temperatureis heated
2. temperatureunder reflux for 2 hours
3. distillationThe ethanol is distilled off under reduced pressure, and water
4. additionis added to the residue
5. extractionThe mixture is extracted with benzene
6. washthe extract is washed with water
7. customdried
8. concentrationconcentrated
9. customto give a reddish brown oil
10. filtrationthe crystalline precipitate is filtered off
11. customrecrystallized from isopropyl ether