反应详情

4.8 g (0.11 mol) of 55 % sodium hydride dispersion are added at 20°-40°C over the course of 1 hour, to 74 g (1.0 mol) of isopentyl alcohol. After stirring for 2 hours at 20°-25°C, 24.4 g (0.10 mol) of 1,6-dibromohexane are added dropwise over the course of 15 minutes. The mixture is stirred at 60°C for 16 hours, then filtered and the filtrate is taken up in ether. The ether solution is extracted with saturated sodium chloride slution, dried with sodium sulphate and evaporated at 40°C/18 mm Hg. After chromatography of the residue on silica gel with hexane/ethyl acetate (99:1) and subsequent distillation (B.P. 85°-87°/1 mm), 1-bromo-6-isopentyloxy-hexane is obtained as a slightly yellow clear liquid.

1. stirringThe mixture is stirred at 60°C for 16 hours
2. filtrationfiltered
3. extractionThe ether solution is extracted with saturated sodium chloride slution
4. dry with materialdried with sodium sulphate
5. customevaporated at 40°C/18 mm Hg
6. distillationAfter chromatography of the residue on silica gel with hexane/ethyl acetate (99:1) and subsequent distillation (B.P. 85°-87°/1 mm)