Acetic Anhydride → HCID 21488089, compound

HRID 1284197Notes

Reaction equation

HRID 1284197 reaction equation
[CH:1]1([C:4](=[O:9])[CH2:5][CH2:6][NH:7][CH3:8])[CH2:3][CH2:2]1.C(=O)([O-])[O-].[K+].[K+].C(O[C:20](=[O:22])[CH3:21])(=O)C>>[CH:1]1([C:4](=[O:9])[CH2:5][CH2:6][N:7]([CH3:8])[C:20](=[O:22])[CH3:21])[CH2:3][CH2:2]1

Participants

4

Reactant 3

HCID 7918Acetic AnhydrideHCID 11430Potassium CarbonateHCID 214880801-Cyclopropyl-3-(methylamino)propan-1-one

Product 1

HCID 21488089HCID 21488089, compound

Procedure

A crude solution of 1-cyclopropyl-3-methylamino-1-propanone was cooled to 8°-10°C. and 8.2 g. (0.06 mole) of potassium carbonate was added, followed by 50 g. (0.5 mole) of acetic anhydride. The mixture was stirred until it warmed to room temperature. The benzne layer was separated, dried over magnesium sulfate, concentrated, and the residual oil distilled at 99°-150°C./0.1 mm. The distillate weighed 65 g. It was calculated to contain 80% of 1-cyclopropyl-3-(N-methylacetamido)-1-propanone by the nuclear magnetic resonance spectrum.

Workup

  1. customThe benzne layer was separated
  2. dry with materialdried over magnesium sulfate
  3. concentrationconcentrated
  4. distillationthe residual oil distilled at 99°-150°C./0.1 mm

Sources & evidence

ORD record
ord-f6d38122ef444bea9c50140b1056c2b5
Source dataset
uspto-grants-1976_08
Patent number
US03978130

Reaction notes

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