Ethyl formate → HCID 20372289, compound

HRID 1284277Notes

Reaction equation

HRID 1284277 reaction equation
[CH3:1][CH:2]([NH2:21])[C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[C:9]([F:20])([F:19])[C:10]([F:18])([F:17])[C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1.[CH2:22]([O:24]C=O)C>>[CH3:1][CH:2]([NH:21][CH:22]=[O:24])[C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[C:9]([F:19])([F:20])[C:10]([F:17])([F:18])[C:11]1[CH:12]=[CH:13][CH:14]=[CH:15][CH:16]=1

Participants

3

Reactant 2

HCID 8025Ethyl formateHCID 20372239HCID 20372239, compound

Product 1

HCID 20372289HCID 20372289, compound

Procedure

α-Methyl-2-(α,α,β,β-tetrafluorophenethyl)-benzylamine, 1.06 g. (0.00357 mole), in 50 ml. of ethylformate is stirred and heated to refluxing for about 21 hours. Evaporation of the solution to dryness and trituration of the residue with hexane gives N-[α-methyl-2-(α,α,β,β-tetrafluorophenethyl)-benzyl]-formamide, m.p. 94.5°-99°C. Recrystallizations from ether-petroleum ether and isopropyl alcohol-water afford a purified sample, m.p. 103°-105°C.

Workup

  1. temperatureheated
  2. temperatureto refluxing for about 21 hours
  3. customEvaporation of the solution to dryness and trituration of the residue with hexane

Sources & evidence

ORD record
ord-4984d1fff32c480f9df6aa1adbe75615
Source dataset
uspto-grants-1976_08
Patent number
US03978127

Reaction notes

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