Allylamine → HCID 21515384, compound

HRID 1284322Notes

Reaction equation

HRID 1284322 reaction equation
[Cl:1][C:2]1[N:3]=[N:4][C:5]([Cl:9])=[CH:6][C:7]=1Cl.[CH2:10]([NH2:13])[CH:11]=[CH2:12]>C(O)C>[Cl:1][C:2]1[N:3]=[N:4][C:5]([Cl:9])=[CH:6][C:7]=1[NH:13][CH2:10][CH:11]=[CH2:12]

Participants

4

Reactant 2

HCID 7853AllylamineHCID 951233,4,6-Trichloropyridazine

Product 1

HCID 21515384HCID 21515384, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

To a stirred solution of 91.7 g of 3,4,6-trichloropyridazine in 1000 ml of ethanol is added slowly with cooling 85.9 g of allylamine. After stirring 2 hours at room temperature, the mixture is cooled and the resultant precipitate 3,6-dichloro-4-allylamino pyridazine is collected by filtration. Concentration of the filtrate to 200 ml gives a second crop and concentration to 100 ml gives a third crop; m.p. 95° to 98°C.

Workup

  1. temperaturethe mixture is cooled
  2. filtrationthe resultant precipitate 3,6-dichloro-4-allylamino pyridazine is collected by filtration
  3. customConcentration of the filtrate to 200 ml gives
  4. concentrationa second crop and concentration to 100 ml
  5. customgives a third crop

Sources & evidence

ORD record
ord-e35f82a558d64bd1a7808ee4b1094236
Source dataset
uspto-grants-1976_08
Patent number
US03978057

Reaction notes

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