Sodium Hydroxide → HCID 21515416, compound

HRID 1284328Notes

Reaction equation

HRID 1284328 reaction equation
[CH2:1]([NH:5][C:6]1[CH:11]=[C:10](Cl)[N:9]=[N:8][C:7]=1[NH:13][NH2:14])[C:2](=[CH2:4])[CH3:3].[OH-].[Na+].[H][H]>CO.[Pd]>[CH2:1]([NH:5][C:6]1[CH:11]=[CH:10][N:9]=[N:8][C:7]=1[NH:13][NH2:14])[CH:2]([CH3:4])[CH3:3]

Participants

6

Reactant 3

HCID 14798Sodium HydroxideHCID 21515372HCID 21515372, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 21515416HCID 21515416, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent2×

Procedure

A solution of 4.0 of 4-methallylamino-6-chloro-3-hydrazinopyridazine in 150 ml. of methanol and 50 ml. of 0.5 N sodium hydroxide in methanol are charged into a Paar shaker. To this solution 2.0 g. of 10% palladium on carbon is added. The Paar shaker is charged with hydrogen at room temperature to an initial pressure of 50 psi and shaken. After about 4 hours, the reaction mixture is filtered, the solvent evaporated and the residue extracted with chloroform. The chloroform is evaporated off and the 4-isobutylamino-3-hydrazinopyridazine obtained is dissolved in methanol. Hydrogen chloride gas is bubbled in, and the product, 4-isobutylamino-3-hydrazinopyridazine hydrochloride (m.p. 211°-212°C.) which precipitates, is collected by filtration.

Workup

  1. filtrationthe reaction mixture is filtered
  2. customthe solvent evaporated
  3. extractionthe residue extracted with chloroform
  4. customThe chloroform is evaporated off

Sources & evidence

ORD record
ord-1e2762c0bb7e46c1bdc472b58113e120
Source dataset
uspto-grants-1976_08
Patent number
US03978057

Reaction notes

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