Sodium Hydroxide → HCID 21515416, compound

Participants

Reaction Steps

A solution of 4.0 of 4-methallylamino-6-chloro-3-hydrazinopyridazine in 150 ml. of methanol and 50 ml. of 0.5 N sodium hydroxide in methanol are charged into a Paar shaker. To this solution 2.0 g. of 10% palladium on carbon is added. The Paar shaker is charged with hydrogen at room temperature to an initial pressure of 50 psi and shaken. After about 4 hours, the reaction mixture is filtered, the solvent evaporated and the residue extracted with chloroform. The chloroform is evaporated off and the 4-isobutylamino-3-hydrazinopyridazine obtained is dissolved in methanol. Hydrogen chloride gas is bubbled in, and the product, 4-isobutylamino-3-hydrazinopyridazine hydrochloride (m.p. 211°-212°C.) which precipitates, is collected by filtration.

Provenance & Evidence