Hydrochloric Acid → HCID 131714481, compound

HRID 1284407Notes

Reaction equation

HRID 1284407 reaction equation
[OH-].[K+].O.COC(=O)[NH:7][C:8]1[N:13]=[C:12]([O:14][CH3:15])[CH:11]=[C:10]([CH:16]([CH3:18])[SeH:17])[N:9]=1.Cl>CO>[CH3:15][O:14][C:12]1[CH:11]=[C:10]([CH:16]([CH3:18])[SeH:17])[N:9]=[C:8]([NH2:7])[N:13]=1

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 962WaterHCID 14797Potassium HydroxideHCID 131714482HCID 131714482, compound

Product 1

HCID 131714481HCID 131714481, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Conditions

Temperature
0 °C

Procedure

To a stirring solution of potassium hydroxide (15.6 mmol) in H2O (77.5 mmol) and 50 ml of methanol was added methyl[4-methoxy-6-(methylselenylmethyl)pyrimidin-2-yl]carbamate (5.2 mmol). The solution was heated to the reflux point for 3 hours, then cooled to 0° C. The solution was neutralized to pH7 with concentrated HCl and then the solvent was removed under reduced pressure. The resulting residue was washed with THF to afford 1.3 g, m.p. 88°-91° C.; NMR (200 MHz, CDCl3): δ 2.01 (s, 3H); 3.48 (s, 2H); 3.85 (s, 3H); 5.1 (br. s, 2H); 5.99 (s, 1H).

Workup

  1. temperatureThe solution was heated to the reflux point for 3 hours
  2. customthe solvent was removed under reduced pressure
  3. washThe resulting residue was washed with THF
  4. customto afford 1.3 g, m.p. 88°-91° C.

Sources & evidence

ORD record
ord-c2cad2dc73cd4acfb7d9535e46ffa56f
Source dataset
uspto-grants-1986_01
Patent number
US04563211

Reaction notes

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