Ethyl bromoacetate → ethoxycarbonylmethyl P-ethyl-2-nitro-5-(2-chloro-4-tri-fluoromethylphenoxy)phenylphosphinate

HRID 1284428Notes

Reaction equation

HRID 1284428 reaction equation
[CH2:1]([P:3]([C:6]1[CH:11]=[C:10]([O:12][C:13]2[CH:18]=[CH:17][C:16]([C:19]([F:22])([F:21])[F:20])=[CH:15][C:14]=2[Cl:23])[CH:9]=[CH:8][C:7]=1[N+:24]([O-:26])=[O:25])(=[O:5])[OH:4])[CH3:2].Br[CH2:28][C:29]([O:31][CH2:32][CH3:33])=[O:30].C(=O)([O-])[O-].[K+].[K+]>CC(=O)CC>[CH2:1]([P:3]([C:6]1[CH:11]=[C:10]([O:12][C:13]2[CH:18]=[CH:17][C:16]([C:19]([F:20])([F:22])[F:21])=[CH:15][C:14]=2[Cl:23])[CH:9]=[CH:8][C:7]=1[N+:24]([O-:26])=[O:25])(=[O:4])[O:5][CH2:28][C:29]([O:31][CH2:32][CH3:33])=[O:30])[CH3:2]

Participants

5

Reactant 3

HCID 7748Ethyl bromoacetateHCID 11430Potassium CarbonateHCID 15589803P-ethyl-2-nitro-5-(2-chloro-4-trifluoromethylphenoxy)phenylphosphinic acid

Product 1

HCID 54516157ethoxycarbonylmethyl P-ethyl-2-nitro-5-(2-chloro-4-tri-fluoromethylphenoxy)phenylphosphinate

Reagents, catalysts & solvents 1

HCID 6569Methyl Ethyl KetoneSolvent

Procedure

In the same manner, P-ethyl-2-nitro-5-(2-chloro-4-trifluoromethylphenoxy)phenylphosphinic acid (500 mg., 1.22 mmol) and ethyl bromoacetate (408 mg, 2.44 mmol) are reacted together with potassium carbonate (253 mg, 1.83 mmol) in 2-butanone (10 ml) to yield ethoxycarbonylmethyl P-ethyl-2-nitro-5-(2-chloro-4-tri-fluoromethylphenoxy)phenylphosphinate.

Sources & evidence

ORD record
ord-eed87c0d5c6d4b05836074267a2fc6d0
Source dataset
uspto-grants-1986_01
Patent number
US04563310

Reaction notes

Loading…