Hydrochloric Acid → HCID 86737660, compound

Participants

Reaction Steps

A solution of 3-acetamido-6-tert.-butyl-thiochromone (31 g) in a 2 N solution (350 ml) of hydrochloric acid in methanol is heated gradually to the reflux temperature and kept at this temperature (70° C.) for 2 hours. After cooling, the reaction medium is poured into an excess of a 10% strength aqueous solution of potassium bicarbonate. A yellow solid precipitates which is filtered off, washed with water and dried. 3-Amino-6-tert.-butyl-thiochromone (26.2 g), which melts at 168° C., is thus obtained.

Provenance & Evidence