Hydrochloric Acid → HCID 86737660, compound

HRID 128444Notes

Reaction equation

HRID 128444 reaction equation
C([NH:4][C:5]1[C:14](=[S:15])[C:13]2[C:8](=[CH:9][CH:10]=[C:11]([C:16]([CH3:19])([CH3:18])[CH3:17])[CH:12]=2)[O:7][CH:6]=1)(=O)C.Cl.C(=O)(O)[O-].[K+]>CO>[NH2:4][C:5]1[C:14](=[S:15])[C:13]2[C:8](=[CH:9][CH:10]=[C:11]([C:16]([CH3:19])([CH3:18])[CH3:17])[CH:12]=2)[O:7][CH:6]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 516893Potassium BicarbonateHCID 86737661HCID 86737661, compound

Product 1

HCID 86737660HCID 86737660, compoundYield 99.7%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A solution of 3-acetamido-6-tert.-butyl-thiochromone (31 g) in a 2 N solution (350 ml) of hydrochloric acid in methanol is heated gradually to the reflux temperature and kept at this temperature (70° C.) for 2 hours. After cooling, the reaction medium is poured into an excess of a 10% strength aqueous solution of potassium bicarbonate. A yellow solid precipitates which is filtered off, washed with water and dried. 3-Amino-6-tert.-butyl-thiochromone (26.2 g), which melts at 168° C., is thus obtained.

Workup

  1. temperatureAfter cooling
  2. customA yellow solid precipitates which
  3. filtrationis filtered off
  4. washwashed with water
  5. customdried

Sources & evidence

ORD record
ord-6029f26cbc254877b7102887492d11d8
Source dataset
uspto-grants-1981_03
Patent number
US04259506

Reaction notes

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