反应详情

To a mixture of 3-amino-2-anilinopyridine (0.5 g), 2-(imidazol-1-yl)acetic acid (0.38 g) and pyridine (0.24 ml) in chloroform (5 ml) was dropwise added phosphorus oxychloride (0.28 ml) and the mixture was refluxed for 1.5 hours. After being cooled, the reaction mixture was decanted and the residue was poured into saturated aqueous sodium bicarbonate. The mixture was extracted three times with ethyl acetate. The combined extract was dried over magnesiumsulfate and the solvent was evaporated under reduced pressure. The resultant residue was triturated in ethyl acetate (10 ml) to give 2-(imidazol-1-yl)-N-(2-anilinopyridin 3-yl)acetamide (200 mg).

1. temperaturethe mixture was refluxed for 1.5 hours
2. temperatureAfter being cooled
3. customthe reaction mixture was decanted
4. additionthe residue was poured into saturated aqueous sodium bicarbonate
5. extractionThe mixture was extracted three times with ethyl acetate
6. extractionThe combined extract
7. dry with materialwas dried over magnesiumsulfate
8. customthe solvent was evaporated under reduced pressure
9. customThe resultant residue was triturated in ethyl acetate (10 ml)