Hydrazine hydrate (1:1) → HCID 178420777, compound

HRID 128452Notes

Reaction equation

HRID 128452 reaction equation
O.[NH2:2]N.C[N:5]([CH:7]=[N:8][C:9](=O)[C:10]1[CH:15]=[CH:14][CH:13]=[N:12][CH:11]=1)C>C(O)(=O)C>[N:5]1[N:2]=[C:9]([C:10]2[CH:11]=[N:12][CH:13]=[CH:14][CH:15]=2)[NH:8][CH:7]=1

Participants

4

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 12550322HCID 12550322, compound

Product 1

HCID 178420777HCID 178420777, compound

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Conditions

Temperature
90 °C

Procedure

To a solution of 3.1 g. of hydrazine hydrate in 100 ml. of acetic acid is added 10.0 g. of N-(dimethylaminomethylene)nicotinamide. The reaction mixture is stirred at 90° C. for 1.5 hours, then concentrated in vacuo to about 15 ml. The addition of 50 ml. of ether causes the desired product to precipitate as 7.8 g. of colorless crystals, mp. 169°-172° C.

Workup

  1. concentrationconcentrated in vacuo to about 15 ml
  2. additionThe addition of 50 ml
  3. customto precipitate as 7.8 g

Sources & evidence

ORD record
ord-1cec5cefea4442099c42e90b2f39e22f
Source dataset
uspto-grants-1981_03
Patent number
US04259504

Reaction notes

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