Water → HCID 13337949, compound

HRID 1284529Notes

Reaction equation

HRID 1284529 reaction equation
[CH:1]1([N:4]2[C:13]3[C:8](=[CH:9][C:10]([N+:20]([O-:22])=[O:21])=[C:11]([N:14]4[CH2:19][CH2:18][NH:17][CH2:16][CH2:15]4)[CH:12]=3)[C:7](=[O:23])[C:6]([C:24]([OH:26])=[O:25])=[CH:5]2)[CH2:3][CH2:2]1.[C:27]([O:31][CH3:32])(=[O:30])[CH:28]=[CH2:29].O>COCCO.CS(C)=O>[CH:1]1([N:4]2[C:13]3[C:8](=[CH:9][C:10]([N+:20]([O-:22])=[O:21])=[C:11]([N:14]4[CH2:19][CH2:18][N:17]([CH2:29][CH2:28][C:27]([O:31][CH3:32])=[O:30])[CH2:16][CH2:15]4)[CH:12]=3)[C:7](=[O:23])[C:6]([C:24]([OH:26])=[O:25])=[CH:5]2)[CH2:2][CH2:3]1

Participants

6

Reactant 3

HCID 962WaterHCID 7294Methyl AcrylateHCID 4594465HCID 4594465, compound

Product 1

HCID 13337949HCID 13337949, compoundYield 75.1%

Reagents, catalysts & solvents 2

HCID 679Dimethyl SulfoxideSolventHCID 80192-MethoxyethanolSolvent

Procedure

537 mg (0.0015) of 1-cyclopropyl-1,4-dihydro-6-nitro-4-oxo-7-(1-piperazinyl)-3-quinolinecarboxylic acid in a mixture of 7.5 ml of glycol monomethyl ether and 3 ml of dimethylsulphoxide are heated under reflux with 2 g of methyl acrylate for 8 hours. 10 ml of water are added to the solution and the precipitate is filtered off with suction, washed with methanol and dried. 0.5 g of 1-cyclopropyl-1,4-dihydro-7-[4-(2-methoxycarbonylethyl)-1-piperazinyl]-6-nitro-4-oxo-3-quinolinecarboxylic acid of decomposition point 208° to 211° C. are obtained.

Workup

  1. temperatureare heated
  2. filtrationthe precipitate is filtered off with suction
  3. washwashed with methanol
  4. customdried

Sources & evidence

ORD record
ord-663abb4c11ee4e19ae1a3567f913c0f5
Source dataset
uspto-grants-1986_01
Patent number
US04563448

Reaction notes

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